Protein Folding, Misfolding and Disease-Related Aggregation

Selected Publications

Siu, H.-W., Hauser, K. "Observation of oligomeric states indicates a high structural flexibility required for the onset of polyQ fibrillization", J. Phys. Chem. Lett., 2022, 13, 4543-4548  [pdf]

Siu, H.-W., Heck, B., Kovermann, M., Hauser, K. "Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation", Chem. Sci., 2021, 12, 412–426 [pdf]

Scheerer, D., Chi, H., McElheny, D., Keiderling, T., Hauser, K. "Enhanced sensitivity to local dynamics in peptides by use of temperature-jump IR-spectroscopy and isotope labeling", Chem. Eur. J., 2020, 26, 3524-3534 [pdf]

Yushchenko, T., Deuerling, E., Hauser, K. "Insights into the aggregation mechanism of polyQ proteins with different glutamine repeat lengths", Biophys. J., 2018, 114, 1847-1857 [pdf]

Fallah, M.A., Gerding, H.R., Scheibe, C., Drescher, M., Karreman, C., Schildknecht, S., Leist, M., Hauser, K. "Simultaneous IR-spectroscopic observation of α-synuclein, lipids, and solvent reveals an alternative membrane-induced oligomerization pathway", ChemBioChem, 2017, 18, 2312 – 2316 pdf

Henke, K., Welte, W., Hauser, K. "Direct monitoring of β-sheet formation in the outer membrane protein TtoA assisted by TtOmp85" Biochemistry2016, 55, 4333–4343 PDF