PostDoc positions

Please contact Prof. Karin Hauser directly, if you are interested to work as a Post-Doc in our group.

PhD positions - we have several openings!

PhD Position in Experimental Molecular Biophysics

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study protein folding dynamics by time-resolved infrared (IR) spectroscopy. In particular, a home-built IR spectrometer with a laser-excited temperature-jump will be used to monitor sub-millisecond structural dynamics. Focus of the project is the understanding of molecular mechanisms in the stabilization of protein structures. Model peptides with novel site-specific infrared probes will be applied to analyze structural dynamics on the basis of individual amino acids, thereby exploring backbone and side-chain dynamics separately

We are looking for a highly motivated student who has successfully completed a master in (bio)physics or chemistry. The ideal candidate should have experience in spectroscopic techniques or laser spectroscopy or optics. Interest in biophysical research and interdisciplinary work is expected. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.

The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available.

Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Karin.Hauser@uni-konstanz.de.

Related publications:

Scheerer, D., Chi, H., McElheny, D., Keiderling, T., Hauser, K. "Enhanced sensitivity to local dynamics in peptides by use of temperature-jump IR-spectroscopy and isotope labeling", Chem Eur J, 2020, 26, 3524-3534

Siu, H., Heck, B., Kovermann, M., Hauser, K. "Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation", Chemical Science 2020, DOI: 10.1039/D0SC05299J

Popp, A., Scheerer, D., Heck, B., Hauser, K. "Biomolecular dynamics studied with IR-spectroscopy using quantum cascade lasers combined with nanosecond perturbation techniques", Spectrochim Acta A Mol Biomol Spectrosc, 2017, 181, 192–199

Details can also be found here [pdf]
Distributed: 01.12.2020

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PhD Position in Biophysical Chemistry

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study molecular interaction mechanisms with infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function.

We are looking for a highly motivated student who has successfully completed a master in (bio)chemistry, (bio)physics, life science or biology. The ideal candidate should have a strong interest in spectroscopy and biophysical research. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.

The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available.

Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Karin.Hauser@uni-konstanz.de.

Related publications:  

Yushchenko, T., Deuerling, E., Hauser, K. "Insights into the aggregation mechanism of polyQ proteins with different glutamine repeat lengths", Biophys. J., 2018, 114, 1847-1857

Krüger, A., Bürkle, A., Hauser, K.*, Mangerich, A.* "Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy", Nat. Commun 2020, 11, 2174

Details can also be found here [pdf]
Distributed: 01.12.2020

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PhD Position in Physical Chemistry

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study CO2 capture in nanoporous, bifunctional organosilica aeorogels as potential strategy to reduce CO2 emission by solid adsorbents. The synthesis of the nanoporous organosilica materials is performed by the collaborating group whereas the focus of this PhD project is the method development of appropriate IR spectroscopic and microscopic approaches including DRIFTS (Diffusive Reflectance Infrared Fourier Transform Spectroscopy) measurements and setting-up a chamber for in-situ IR microscopy. CO2 gas adsorption will be analyzed for various organosilica materials to understand molecular interactions, kinetics and the functional role of water during the CO2 adsorption. This project is funded by the DFG and can start immediately.

We are looking for a highly motivated student who has successfully completed a master in chemistry or physics. The candidate should preferably have experience in spectroscopic techniques. Interest in method development and materials science is expected. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.

Please send your application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Karin.Hauser@uni-konstanz.de.

Details can also be found here [pdf]
Distributed: 01.12.2020

Bachelor/Master projects

Candidates interested in Bachelor or Master projects in the area of (bio)molecular spectroscopy are most welcome to get in touch anytime to discuss possible projects.

For more detailed information about the projects please contact Prof. Karin Hauser.

Student projects

Students who are interested in getting to know our group and the field of molecular spectroscopy are at any time welcome to get in touch about a semester project.

Open Positions

Post-Doc

Please contact Prof. Dr. Karin Hauser directly, if you are interested to work as a Post-Doc in our group.

Doktor-Arbeiten

Das Thema der Doktorarbeit befasst sich mit der Untersuchung von Proteinfaltungsdynamik mittels zeitaufgelöster IR-Laserspektroskopie. Ein Teil der Arbeit umfasst die Weiterentwicklung eines IR-Laserspektrometers. Dabei kommen u.a. Quantenkaskadenlaser zum Einsatz. Faltungsprozesse sollen anhand von Modellpeptiden und Proteinfragmenten auf Basis einzelner Aminosäuren und mit Hilfe spektroskopischer Sonden untersucht werden.  

  • Voraussetzung: Master- bzw. Diplomabschluss in Physik/Chemie; Interesse an experimenteller Entwicklungsarbeit im Bereich Optik/Spektroskopie und am interdisziplinären Arbeiten auf dem Forschungsgebiet der molekularen Biophysik; Erfahrungen im Bereich Optik/Laserspektroskopie sind von Vorteil.
  • Anfangsdatum: ab sofort; geschätzte Dauer: 3 Jahre
  • Bezahlung: 50% TV-L 13

Schriftliche Bewerbungen, gerne auch in elektronischer Form, mit den üblichen Unterlagen (Lebenslauf, Zeugnisse, bisherige Arbeitsgebiete) bitte an Prof. Dr. Karin Hauser schicken.

Master-Arbeiten

Experimentell:

  • Kinetische Untersuchungen mittels licht-induziertem pH-Sprung
  • Untersuchung der Konformationsdynamik von alpha-synuclein an Membranoberflächen 
  • Zeitaufgelöste Infrarot-Messungen zum Faltungsmechanismus kleiner Peptide
  • Stopped-Flow IR-Messungen zur Untersuchung von Pränukleations-Intermediaten in Mineralisationsprozessen
  • Analyse und Quantifizierung der Mess-Artefakte eines laser-induzierten Temperatursprungs mittels Raman-Shifter

Computergestützt-theoretisch:

  • Untersuchung der Calciumwege in der Ca2+-ATPase mittels einer Kombination aus Elektrostatik und Molekulardynamik
  • Simulationsrechnungen zur Untersuchung elektrostatischer Felder in Proteinen

Bachelor-Arbeiten

Experimentell:

  • FTIR-Messungen von Strukturumwandlungen kleiner Biomolekülen mit Isotopenmarkierungen als Sonden
  • Charakterisierung der Stabilität von glutamin-basierten Hairpin-Peptiden
  • Spektroskopische Untersuchung von Aggregationsprozessen auf Membranoberflächen
  • Disaggregation von PolyQ-Peptiden

Computergestützt-theoretisch:

  • Einfluss von Kristallstruktur-Inhibitoren auf berechnete pK-Werte
  • Entwicklung von Membranmodellen für Simulationsrechnungen an Membranproteinen

Studentische Hilfskräfte

[noch aktuell?]

Tutor für die Übungsgruppe PC für Übungsgruppe PC II im WS 2012/13 

  • Einstellung als wissenschaftliche Hilfskraft
  • Voraussetzungen:MA-Student Chemie /Life Sciencemit sehr guten Kenntnissen in Quantenchemie/Spektroskopie/Kinetik
  • Bei Interesse bitte per E-mail bei Prof. Dr. Karin Hauser melden.