Publications
112. Phosphonate and Thiasugar Analogues of Glucosamine-6-phosphate: Activation of the glmS Riboswitch and Antibiotic Activity
B. Silkenath, D. Kläge, H. Altwein, N. Schmidhäuser, G. Mayer, J. S. Hartig, V. Wittmann, ACS Chem. Biol. 2023, 18, DOI: 10.1021/acschembio.3c00452.
DOI: 10.1021/acschembio.3c00452 Supporting Information - PDF
111. Use of Metabolic Glycoengineering and Pharmacological Inhibitors to Assess Lipid and Protein Sialylation on Cells
P. Kranaster, J. Blum, J. E. G. A. Dold, V. Wittmann, M. Leist, J. Neurochem. 2023, 164, 481-498.
DOI: 10.1111/jnc.15737 Supporting Information - PDF
110. Metabolic Glycoengineering – Exploring Glycosylation with Bioorthogonal Chemistry
M. Kufleitner,+ L. M. Haiber,+ V. Wittmann, Chem. Soc. Rev. 2023, 52, 510-535.
DOI: 10.1039/D2CS00764A
109. Carba-Sugar Analogs of Glucosamine-6-Phosphate: New Activators for the glmS Riboswitch
D. Stängle,+ B. Silkenath,+ P. Gehle, A. Esser, G. Mayer, V. Wittmann, Chem. Eur. J. 2023, 29, e202202378.
DOI: 10.1002/chem.202202378 Supporting Information - PDF
108. Photoswitching Affinity and Mechanism of Multivalent Lectin Ligands
U. Osswald, J. Boneberg, V. Wittmann, Chem. Eur. J. 2022, 28, e202200267.
DOI: 10.1002/chem.202200267 Supporting Information - PDF
107. Using Polymeric Hydroxypropyl Methylcellulose as an Alternative to "Micellar Catalysis" to Enable Chemical Reactions in Water
N. Borlinghaus, V. Wittmann, W. M. Braje, Curr. Opin. Green Sust. Chem. 2022, 33, 100571.
DOI: 10.1016/j.cogsc.2021.100571
106. An Advanced ‘clickECM’ that Can be Modified by the Inverse-Electron Demand Diels-Alder Reaction
S. Nellinger, M. A. Rapp, A. Southan, V. Wittmann, P. J. Kluger, ChemBioChem 2022, 23, e202100266.
DOI: 10.1002/cbic.202100266 Supporting Information - PDF
105. In situ EPR Spectroscopy of a Bacterial Membrane Transporter Using an Expanded Genetic Code
A. Kugele, S. Ketter, B. Silkenath, V. Wittmann, B. Joseph, M. Drescher, Chem. Commun. 2021, 57, 12980-12983.
DOI: 10.1039/D1CC04612H Supporting Information - PDF
104. Rapid Glycoconjugation with Glycosyl Amines
M. A. Rapp, O. R. Baudendistel, U. E. Steiner, V. Wittmann, Chem. Sci. 2021, 12, 14901-14906.
DOI: 10.1039/D1SC05008G Supporting Information - PDF
103. Nucleophilic Aromatic Substitution Reactions under Aqueous, Mild Conditions Using Polymeric Additive HPMC
N. Borlinghaus, T. N. Ansari, L. H. Braje, D. Ogulu, S. Handa, V. Wittmann, W. M. Braje, Green Chem. 2021, 23, 3955-3962.
DOI: 10.1039/D1GC00128K Supporting Information - PDF
102. Application of the Inverse-Electron-Demand Diels-Alder Reaction for Metabolic Glycoengineering
L. M. Haiber,+ M. Kufleitner,+ V. Wittmann, Front. Chem. 2021, 9, 654932.
DOI: 10.3389/fchem.2021.654932
101. Ligand-Programmed Consecutive Symmetry Break(s) in Nanoparticle Based Materials Showing Emergent Phenomena: Transitioning from Sixfold to Threefold Symmetry in Anisotropic ZnO Colloids
S. Theiss, M. Voggel, H. Kuper, M. Hoermann, U. Krings, P. Baum, J. A. Becker, V. Wittmann, S. Polarz, Adv. Funct. Mater. 2021, 31, 2009104.
DOI: 10.1002/adfm.202009104 Supporting Information - PDF
100. Metabolic Glycoengineering with Azide- and Alkene-Modified Hexosamines: Quantification of Sialic Acid Levels
J. E. G. A. Dold, V. Wittmann, ChemBioChem 2021, 22, 1243-1251.
DOI: 10.1002/cbic.202000715 Supporting Information - PDF
99. Optimising broadband pulses for DEER depends on concentration and distance range of interest
A. Scherer, S. Tischlik, S. Weickert, V. Wittmann, M. Drescher, Magn. Reson. 2020, 1, 59-74.
DOI: 10.5194/mr-1-59-2020 Supporting Information - PDF (Size: 2.397k)
98. Precipitation-Free High-Affinity Multivalent Binding by Inline Lectin Ligands
P. Rohse, S. Weickert, M. Drescher, V. Wittmann, Chem. Sci. 2020, 11, 5227-5237.
DOI: 10.1039/D0SC01744B Supporting Information - PDF (Size: 2.180k)
97. Time and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity
P. Kranaster, C. Karreman, J. E. G. A. Dold, A. Krebs, M. Funke, A.-K. Holzer, S. Klima, J. Nyffeler, S. Helfrich, V. Wittmann, M. Leist, Arch. Toxicol. 2020, 94, 449-467.
DOI: 10.1007/s00204-019-02642-z Supporting Information - PPTX (Size: 17.492k)
96. Machine Learning Prediction of Cyanobacterial Toxin (Microcystin) Toxicodynamics in Humans
S. Altaner, S. Jaeger, R. Fotler, I. Zemskov, V. Wittmann, F. Schreiber, D. R. Dietrich, ALTEX 2020, 37, 24-36.
DOI: 10.14573/altex.1904031 Supporting Information - PDF (Size: 1.082k)
95. Generation of an azide-modified extracellular matrix by adipose-derived stem cells using metabolic glycoengineering
S. Nellinger, S. Keller, A. Southan, V. Wittmann, A.-C. Volz, P. J. Kluger, Curr. Dir. Biomed. Eng. 2019, 5, 393-395.
DOI: 10.1515/cdbme-2019-0099
94. A Tripeptide Approach to the Solid-Phase Synthesis of Peptide Thioacids and N-Glycopeptides
M. J. Schöwe, O. Keiper, C. Unverzagt, V. Wittmann, Chem. Eur. J. 2019, 25, 15759-15764.
DOI: 10.1002/chem.201904688 Supporting Information - PDF (Size: 3.280k)
93. Human MRP2 Exports MC-LR but not the Glutathione Conjugate
G. Kaur, R. Fahrner, V. Wittmann, B. Stieger, D. R. Dietrich, Chem.-Biol. Interact. 2019, 311, 108761.
DOI: 10.1016/j.cbi.2019.108761
92. Simultaneous Detection of 14 Microcystin Congeners from Tissue Samples Using UPLC-ESI-MS/MS and Two Different Deuterated Synthetic Microcystins as Internal Standards
S. Altaner, J. Puddick, V. Fessard, D. Feurstein, I. Zemskov, V. Wittmann, D. R. Dietrich, Toxins 2019, 11, 388.
DOI: 10.3390/toxins11070388 Supporting Information - PDF (Size: 607k)
91. Protein Spin Labeling with a Photocaged Nitroxide Using Diels-Alder Chemistry
A. Kugele,+ B. Silkenath,+ J. Langer, V. Wittmann, M. Drescher, ChemBioChem 2019, 20, 2479-2484.
DOI: 10.1002/cbic.201900318 Supporting Information - PDF (Size: 2.104k)
90. Cyclopropene Derivatives of Aminosugars for Metabolic Glycoengineering
J. Hassenrück, V. Wittmann, Beilstein J. Org. Chem. 2019, 15, 584-601.
DOI: 10.3762/bjoc.15.54 Supporting Information - PDF (Size: 2.515k)
89. Multivalent Carbohydrate-Functionalized Polymer Nanocrystals
Q. Tong, M. S. Schmidt, V. Wittmann, S. Mecking, Biomacromolecules 2019, 20, 294-304.
DOI: 10.1021/acs.biomac.8b01460 Supporting Information - PDF (Size: 2.449k)
88. Triple Orthogonal Labeling of Glycans Applying Photoclick Chemistry
V. F. Schart, J. Hassenrück, A.-K. Späte, J. E. G. A. Dold, R. Fahrner, V. Wittmann, ChemBioChem 2019, 20, 166-171.
DOI: 10.1002/cbic.201800740 Supporting Information - PDF (Size: 2.319k)
87. Conformationally Unambiguous Spin Label for Exploring the Binding Site Topology of Multivalent Systems
S. Weickert, T. Seitz, W. K. Myers, C. R. Timmel, M. Drescher, V. Wittmann, J. Phys. Chem. Lett. 2018, 9, 6131-6135.
DOI: 10.1021/acs.jpclett.8b02243 Supporting Information - PDF (Size: 2.380k)
86. Sweet surfactants: packing parameter-invariant amphiphiles as emulsifiers and capping agents for morphology control of inorganic particles
M. Voggel, R. M. Meinusch, V. Siewert, M. Kunkel, V. Wittmann, S. Polarz, Soft Matter 2018, 14, 7214-7227.
DOI: 10.1039/c8sm01091a Supporting Information 1 - PDF (Size: 6.402k) Supporting Information 2 - PDF (Size: 1.060k)
85. Identification of D-Amino Acid Oxidase and Propiverine Interaction Partners and their Potential Role in the Propiverine-Mediated Nephropathy
M. Y. Maier, L. Luks, O. Baudendistel, V. Wittmann, D. R. Dietrich, Chem.-Biol. Interact. 2018, 281, 69-80.
DOI: 10.1016/j.cbi.2017.12.023 Supporting Information - PDF (Size: 431k)
84. Intracellular Imaging of Protein-Specific Glycosylation
F. Doll, J. Hassenrück, V. Wittmann, A. Zumbusch, Methods Enzymol. 2018, 598, 283-319.
DOI: 10.1016/bs.mie.2017.06.015
83. Fluoro-carba-sugars are Glycomimetic Activators of the glmS Ribozyme
D. Matzner, A. Schüller, T. Seitz, V. Wittmann, G. Mayer, Chem. Eur. J. 2017, 23, 12604-12612.
DOI: 10.1002/chem.201702371 Supporting Information - PDF (Size: 5.229k)
82. Dienophile-Modified Mannosamine Derivatives for Metabolic Labeling of Sialic Acids: A Comparative Study
J. E. G. A. Dold, J. Pfotzer, A.-K. Späte, V. Wittmann, ChemBioChem 2017, 18, 1242-1250.
DOI: 10.1002/cbic.201700002 Supporting Information - PDF (Size: 2.279k)
81. Total Synthesis of Microcystin-LF and Derivatives Thereof
I. Zemskov, S. Altaner, D. R. Dietrich, V. Wittmann, J. Org. Chem. 2017, 82, 3680-3691.
DOI: 10.1021/acs.joc.7b00175 Supporting Information - PDF (Size: 3.426k)
80. Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition
A. Schüller, D. Matzner, C. E. Lünse, V. Wittmann, C. Schumacher, S. Unsleber, H. Brötz-Oesterhelt, C. Mayer, G. Bierbaum, G. Mayer, ChemBioChem 2017, 18, 435-440.
DOI: 10.1002/cbic.201600491 Supporting Information - PDF (Size: 395k)
79. clickECM: Development of a Cell-Derived Extracellular Matrix with Azide Functionalities
S. M. Ruff,+ S. Keller,+ D. E. Wieland, V. Wittmann, G. E. M. Tovar, M. Bach, P. J. Kluger, Acta Biomater. 2017, 52, 159-170.
DOI: 10.1016/j.actbio.2016.12.022 Supporting Information - PDF (Size: 886k)
78. Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1
M. Fontanillo, I. Zemskov, M. Häfner, U. Uhrig, F. Salvi, B. Simon, V. Wittmann, M. Köhn, Angew. Chem. 2016, 128, 14191-14195; Angew. Chem., Int. Ed. 2016, 55, 13985-13989.
DOI: 10.1002/ange.201606449 (German) DOI: 10.1002/anie.201606449 (English) Supporting Information - PDF (Size: 7.021k)
77. Real-Time NMR Studies of Oxyamine Ligations of Reducing Carbohydrates under Equilibrium Conditions
O. R. Baudendistel,+ D. E. Wieland,+ M. S. Schmidt, V. Wittmann, Chem. Eur. J. 2016, 22, 17359-17365.
DOI: 10.1002/chem.201603369 Supporting Information - PDF (Size: 2.744k)
76. Regioselective Cleavage of Thioether Linkages in Microcystin-Conjugates
I. Zemskov, H. M. Kropp, V. Wittmann, Chem. Eur. J. 2016, 22, 10990-10997.
DOI: 10.1002/chem.201601660 Supporting Information - PDF (Size: 1.225k)
75. Synthetic Glycosphingolipids for Live-Cell Labeling
M. Dauner,+ E. Batroff,+ V. Bachmann, C. R. Hauck, V. Wittmann, Bioconjugate Chem. 2016, 27, 1624-1637.
DOI: 10.1021/acs.bioconjchem.6b00177 Supporting Information - PDF (Size: 2.216k)
74. Exploring the Potential of Norbornene-Modified Mannosamine Derivatives for Metabolic Glycoengineering
A.-K. Späte, J. E. G. A. Dold, E. Batroff, V. F. Schart, D. E. Wieland, O. R. Baudendistel, V. Wittmann, ChemBioChem 2016, 17, 1374-1383.
DOI: 10.1002/cbic.201600197 Supporting Information - PDF (Size: 1.127k)
73. Mechanistic Insight into Nanomolar Binding of Multivalent Neoglycopeptides to Wheat Germ Agglutinin
P. Rohse, V. Wittmann, Chem. Eur. J. 2016, 22, 9724-9733.
DOI: 10.1002/chem.201600657 Supporting Information - PDF (Size: 1.211k)
72. Distinct CCR7 Glycosylation Pattern Shapes Receptor Signaling and Endocytosis to Modulate Chemotactic Responses
M. A. Hauser, I. Kindinger, J. M. Laufer, A.-K. Späte, D. Bucher, S. L. Vanes, W. A. Krueger, V. Wittmann, D. F. Legler, J. Leukocyte Biol. 2016, 99, 993-1007.
DOI: 10.1189/jlb.2VMA0915-432RR
71. The STEAP1262-270 Peptide Encapsulated into PLGA Microspheres Elicits Strong Cytotoxic T Cell Immunity in HLA-A*0201 Transgenic Mice - A New Approach to Immunotherapy Against Prostate Carcinoma
V. L. Herrmann, D. E. Wieland, D. F. Legler, V. Wittmann, M. Groettrup, Prostate 2016, 76, 456-468.
DOI: 10.1002/pros.23136
70. -- Hot Paper -- Visualization of Protein-Specific Glycosylation inside Living Cells
F. Doll, A. Buntz, A.-K. Späte, V. F. Schart, A. Timper, W. Schrimpf, C. R. Hauck, A. Zumbusch, V. Wittmann, Angew. Chem. 2016, 128, 2303-2308; Angew. Chem., Int. Ed. 2016, 55, 2262-2266.
DOI: 10.1002/ange.201503183 (German) DOI: 10.1002/anie.201503183 (English) Supporting Information - PDF (Size: 1.553k)
69. Orthogonally Protected Furanoid Sugar Diamino Acids for Solid-Phase Synthesis of Oligosaccharide Mimetics
F. John, V. Wittmann, J. Org. Chem. 2015, 80, 7477-7485.
DOI: 10.1021/acs.joc.5b01049 Supporting Information - PDF (Size: 1.288k)
68. Application of the Thioacid-Azide Ligation (TAL) for the Preparation of Glycosylated and Fluorescently Labeled Amino Acids
K. Rohmer, J. Mannuthodikayil, V. Wittmann, Isr. J. Chem. 2015, 55, 437-446.
DOI: 10.1002/ijch.201500001 Supporting Information - PDF (Size: 1.932k)
67. Chapter 28. Short Synthesis of (2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-ß-D-glucopyranosyl)benzene and 4-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-ß -D-glucopyranosyl)bromobenzene
T. Seitz, C. Fleck, V. Wittmann, in Carbohydrate Chemistry: Proven Synthetic Methods, Vol. 3 (Eds.: R. Roy, S. Vidal), CRC Press, Boca Raton, 2015, 219-225.
DOI: 10.1201/b18400-31
66. Chapter 27. 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-O-p- nitrophenoxycarbonyl-a-D-glucopyranose
T. Seitz, C. Maierhofer, D. Matzner, V. Wittmann, in Carbohydrate Chemistry: Proven Synthetic Methods, Vol. 3 (Eds.: R. Roy, S. Vidal), CRC Press, Boca Raton, 2015, 215-218.
DOI: 10.1201/b18400-30
65. -- Hot Paper -- Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering
A.-K. Späte,+ V. F. Schart,+ S. Schöllkopf, A. Niederwieser, V. Wittmann, Chem. Eur. J. 2014, 20, 16502-16508.
DOI: 10.1002/chem.201404716 Supporting Information - PDF (Size: 1.257k)
64. Expanding the Scope of Cyclopropene Reporters for the Detection of Metabolically Engineered Glycoproteins by Diels-Alder Reactions
A.-K. Späte, V. F. Schart, J. Häfner, A. Niederwieser, T. U. Mayer, V. Wittmann, Beilstein J. Org. Chem. 2014, 10, 2235-2242.
DOI: 10.3762/bjoc.10.232 Supporting Information - PDF (Size: 1.119k)
63. Efficient Labelling of Enzymatically Synthesized Vinyl-Modified DNA by an Inverse-Electron-Demand Diels-Alder Reaction
H. Bußkamp, E. Batroff, A. Niederwieser, O. S. Abdel-Rahman, R. Winter, V. Wittmann, A. Marx, Chem. Commun. 2014, 50, 10827-10829.
DOI: 10.1039/C4CC04332D Supporting Information - PDF (Size: 553k)
62. Neues zur Physiologie des Labyrinths
H. Scherer, J. Dernedde, W. Reutter, R. Tauber, V. Wittmann, A. Niederwieser, in Vertigo - Neue Horizonte in Diagnostik und Therapie (9. Henning Symposium) (Eds.: A. Ernst, D. Basta), Springer, Wien, 2014, pp. 3-10.
61. Trendbericht Biochemie und Molekularbiologie 2013: Kohlenhydrate - mehr als nur Energielieferanten
V. Wittmann, V. F. Schart, A.-K. Späte, Nachr. Chem. 2014, 62, 306-312.
DOI: 10.1002/nadc.201490087
60. Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter
A.-K. Späte, H. Bußkamp, A. Niederwieser, V. F. Schart, A. Marx, V. Wittmann, Bioconjugate Chem. 2014, 25, 147-154.
DOI: 10.1021/bc4004487 Supporting Information - PDF (Size: 1.867k)
59. Structural Investigation of Multivalent Carbohydrate-Protein Interactions using Synthetic Biomolecules
V. Wittmann, Curr. Opin. Chem. Biol. 2013, 17, 982-989.
DOI: 10.1016/j.cbpa.2013.10.010
58. Bridging Lectin Binding Sites by Multivalent Carbohydrates
V. Wittmann, R. J. Pieters, Chem. Soc. Rev. 2013, 42, 4492-4503.
DOI: 10.1039/c3cs60089k
57. Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry
A. Niederwieser, A.-K. Späte, L. D. Nguyen, C. Jüngst, W. Reutter, V. Wittmann, Angew. Chem. 2013, 125, 4359-4363; Angew. Chem., Int. Ed. 2013, 52, 4265-4268.
DOI: 10.1002/ange.201208991 (German) DOI: 10.1002/anie.201208991 (English) Supporting Information - PDF (Size: 2.295k)
56. High-Affinity Multivalent Wheat Germ Agglutinin Ligands by One-Pot Click Reaction
H. S. G. Beckmann, H. M. Möller, V. Wittmann, Beilstein J. Org. Chem. 2012, 8, 819-826.
DOI: 10.3762/bjoc.8.91 Supporting Information - PDF (Size: 776k)
55. Preparation of Carbohydrate Arrays by using Diels–Alder Reactions with Inverse-Electron-Demand
H. S. G. Beckmann, A. Niederwieser, M. Wiessler, V. Wittmann, Chem. Eur. J. 2012, 18, 6548-6554.
DOI: 10.1002/chem.201200382 Supporting Information - PDF (Size: 931k)
54. Abstand halten: Aufklärung multivalenter Bindungsmechanismen
V. Wittmann, M. Drescher, Laborpraxis 2012, 36 (Februar), 42-44.
Full Text - PDF (Size: 318k) Online Article
53. Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus
C. E. Lünse, M. S. Schmidt, V. Wittmann*, G. Mayer*, ACS Chem. Biol. 2011, 6, 675-678.
DOI: 10.1021/cb200016d Supporting Information - PDF (Size: 4.455k)
52. Mechanism of Multivalent Carbohydrate-Protein Interactions Studied by EPR Spectroscopy
P. Braun, B. Nägele, V. Wittmann*, M. Drescher, Angew. Chem. 2011, 123, 8579-8582; Angew. Chem. Int. Ed. 2011, 50, 8428-8431.
DOI: 10.1002/ange.201101074 (German) DOI: 10.1002/anie.201101074 (English) Supporting Information - PDF (Size: 1.697k)
51. Preparation of Thioacid-Containing Amino Acids and Peptides and their Application in Ligation Reactions
K. Rohmer, O. Keiper, J. Mannuthodikayil, V. Wittmann, in Peptides 2010: Tales of Peptides (Proc. 31st European Peptide Symposium) (Eds.: M. Lebl, M. Meldal, K. J. Jensen, T. Hoeg-Jensen), European Peptide Society, 2010, pp. 218-219.
Full Text - PDF (Size: 477k)
50. Rapid Screening of Lectins for Multivalency Effects with a Glycodendrimer Microarray
N. Parera Pera, H. M. Branderhorst, R. Kooij, C. Maierhofer, M. van der Kaaden, R. M. J. Liskamp, V. Wittmann, R. Ruijtenbeek, R. J. Pieters, ChemBioChem 2010, 11, 1896-1904.
DOI: 10.1002/cbic.201000340 Supporting Information - PDF (Size: 13.565k)
49. Structural Basis of Multivalent Binding to Wheat Germ Agglutinin
D. Schwefel, C. Maierhofer, J. G. Beck, S. Seeberger, K. Diederichs, H. M. Möller, W. Welte, V. Wittmann, J. Am. Chem. Soc. 2010, 132, 8704-8719.
DOI: 10.1021/ja101646k Supporting Information - PDF (Size: 5.697k)
48. Muropeptide Rescue in Bacillus Subtilis Involves Sequential Hydrolysis by b-N-Acetylglucosaminidase and N-Acetylmuramyl-L-alanine Amidase
S. Litzinger, A. Duckworth, K. Nitzsche, C. Risinger, V. Wittmann, C. Mayer, J. Bacteriol. 2010, 192, 3132-3143.
DOI: 10.1128/jb.01256-09 Supporting Information - PDF (Size: 1.690k)
47. De novo Sequencing of Peptides on Single Resin Beads by MALDI-FTICR Tandem Mass Spectrometry
A. Semmler, R. Weber, M. Przybylski, V. Wittmann, J. Am. Soc. Mass Spectrom. 2010, 21, 215-219.
DOI: 10.1016/j.jasms.2009.10.004
46. Azides in Carbohydrate Chemistry
H. S. G. Beckmann, V. Wittmann, in Organic Azides: Syntheses and Applications (Eds.: S. Bräse, K. Banert), John Wiley & Sons, Chichester, 2010, pp. 469-490.
DOI: 10.1002/9780470682517.ch16
45. Carbamate-Linked Lactose: Design of Clusters and Evidence for Selectivity to Block Binding of Human Lectins to (Neo)Glycoproteins with Increasing Degree of Branching and to Tumor Cells
S. André, D. Specker, N. V. Bovin, M. Lensch, H. Kaltner, H.-J. Gabius, V. Wittmann, Bioconjugate Chem. 2009, 20, 1716-1728.
DOI: 10.1021/bc900152w
44. Stereoselective Synthesis of 1,1'-Linked a-L-Lyxopyranosyl b-D-Glucopyranoside, the Proposed Biosynthetic Precursor of the FG Ring System of Avilamycins
M. S. Schmidt, V. Wittmann, Carbohydr. Res. 2008, 343, 1612-1623.
DOI: 10.1016/j.carres.2008.05.004
43. Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule
L. Merkel, H. S. G. Beckmann, V. Wittmann*, N. Budisa*, ChemBioChem 2008, 9, 1220-1224.
DOI: 10.1002/cbic.200800050 Supporting Information - PDF (Size: 232k)
42. Glycoproteins: Properties
V. Wittmann, in Glycoscience: Chemistry and Chemical Biology (Eds.: B. Fraser-Reid, K. Tatsuta, J. Thiem), 2nd ed., Springer-Verlag, Heidelberg, 2008, pp. 1771-1793.
DOI: 10.1007/978-3-540-30429-6_44
41. Glycoproteins: Occurrence and Significance
V. Wittmann, in Glycoscience: Chemistry and Chemical Biology (Eds.: B. Fraser-Reid, K. Tatsuta, J. Thiem), 2nd ed., Springer-Verlag, Heidelberg, 2008, pp. 1735-1770.
DOI: 10.1007/978-3-540-30429-6_43
40. Unexpected formation of complex bridged tetrazoles via intramolecular 1,3-dipolar cycloaddition of 1,2-O-cyanoalkylidene derivatives of 3-azido-3-deoxy-D-allose
M. Worch, V. Wittmann, Carbohydr. Res. 2008, 343, 2118-2129.
DOI: 10.1016/j.carres.2007.10.034
39. Probing Multivalent Carbohydrate-Lectin Interactions by an Enzyme-Linked Lectin Assay Employing Covalently Immobilized Carbohydrates
C. Maierhofer, K. Rohmer, V. Wittmann, Bioorg. Med. Chem 2007, 15, 7661-7676.
DOI: 10.1016/j.bmc.2007.08.063
38. Synthesis and Application of Glycopeptide and Glycoprotein Mimetics
D. Specker, V. Wittmann, Top. Curr. Chem. 2007, 267, 65-107.
DOI: 10.1007/128_2006_104
37. Glycopeptides and Glycoproteins: Synthesis, Structure, and Application (Topics in Current Chemistry, vol. 267)
V. Wittmann (Ed.), Springer, Berlin Heidelberg New York, 2007.
DOI: 10.1007/978-3-540-36761-1
36. One-Pot Procedure for Diazo Transfer and Azide-Alkyne Cycloaddition: Triazole Linkages from Amines
H. S. G. Beckmann, V. Wittmann, Org. Lett. 2007, 9, 1-4.
DOI: 10.1021/ol0621506 Supporting Information - PDF (Size: 246k)
Rank 4 of the most-accessed articles of Organic Letters of the year 2007!
35. The Organic Chemistry of Sugars (Eds.: D. E. Levy, P. Fügedi) (Book Review)
V. Wittmann, Angew. Chem. 2006, 118, 3477-3478; Angew. Chem. Int. Ed. 2006, 45, 3399-3400.
DOI: 10.1002/ange.200685377 (German) DOI: 10.1002/anie.200685377 (English)
34. Orthogonally Protected Sugar Diamino Acids as Building Blocks for Linear and Branched Oligosaccharide Mimetics
F. Sicherl, V. Wittmann, Angew. Chem. 2005, 117, 2133-2136; Angew. Chem. Int. Ed. 2005, 44, 2096-2099.
DOI: 10.1002/ange.200462595 (German) DOI: 10.1002/anie.200462595 (English) Supporting Information - PDF (Size: 173k)
33. Orthogonally Protected Sugar Diamino Acids as Building Blocks for Oligosaccharide Mimetics
F. Sicherl, V. Wittmann, in Peptide Revolution: Genomics, Proteomics & Therapeutics (Proc. 18th American Peptide Symposium) (Eds.: M. Chorev, T. K. Sawyer), American Peptide Society, San Diego, 2004, 161-162.
Full Text - PDF (Size: 237k)
32. Synthetic Approaches to Study Multivalent Carbohydrate-Lectin Interactions
V. Wittmann, in Highlights in Bioorganic Chemistry: Methods and Applications (Eds.: C. Schmuck, H. Wennemers), Wiley-VCH, Weinheim, 2004, 203-213.
DOI: 10.1002/3527603727.ch2g
31. Molecular Basis of Protein-Carbohydrate Interactions
A. Lützen, V. Wittmann, in Highlights in Bioorganic Chemistry: Methods and Applications (Eds.: C. Schmuck, H. Wennemers), Wiley-VCH, Weinheim, 2004, 119-123.
30. Spatial Screening of Cyclic Neoglycopeptides: Identification of Polyvalent Wheat-Germ Agglutinin Ligands
V. Wittmann, S. Seeberger, Angew. Chem. 2004, 116, 918-921; Angew. Chem. Int. Ed. 2004, 43, 900-903.
DOI: 10.1002/ange.200352055 (German) DOI: 10.1002/anie.200352055 (English) Supporting Information - PDF (Size: 762k)
29. NMR Spectroscopic Determination of the Solution Structure of a Branched Nucleic Acid from Residual Dipolar Couplings by Using Isotopically Labeled Nucleotides
B. N. M. van Buuren, J. Schleucher, V. Wittmann, C. Griesinger, H. Schwalbe, S. S. Wijmenga, Angew. Chem. 2004, 116, 189-194; Angew. Chem. Int. Ed. 2004, 43, 187-192.
DOI: 10.1002/ange.200351632 (German Ed.) DOI: 10.1002/anie.200351632 (Int. Ed.) Supporting Information - PDF (Size: 159k)
28. Temporary Attachment of Carbohydrates to Cyclopeptide Templates: A New Strategy for Single-Bead Analysis of Multivalent Glycopeptides
V. Wittmann, S. Seeberger, H. Schägger, Tetrahedron Lett. 2003, 44, 9243-9246.
DOI: 10.1016/j.tetlet.2003.10.078
27. Sweet Pages (Website Review)
V. Wittmann, Angew. Chem. 2002, 114, 3195; Angew. Chem. Int. Ed. 2002, 41, 3067.
DOI: 10.1002/1521-3757(20020816)114:16%3C3195::AID-ANGE3195%3E3.0.CO;2-Q (German) DOI: 10.1002/1521-3773(20020816)41:16%3C3067::AID-ANIE3067%3E3.0.CO;2-S (English)
26. RNA-Targeting mit Aminoglycosid-Analoga
V. Wittmann, Nachr. Chem. 2002, 50, 1364-1368.
DOI: 10.1002/nadc.20020501219
25. Neues von der Suzuki-Reaktion
V. Wittmann, Nachr. Chem. 2002, 50, 1122-1127.
DOI: 10.1002/nadc.20020501016
24. Totalsynthesen von Callipeltosid A
V. Wittmann, Nachr. Chem. 2002, 50, 841-845.
DOI: 10.1002/nadc.20020500716
23. Dynamische kombinatorische Bibliotheken
V. Wittmann, Nachr. Chem. 2002, 50, 724-727.
DOI: 10.1002/nadc.20020500617
22. Die Totalsynthese von vermeintlichem Diazonamid A
V. Wittmann, Nachr. Chem. 2002, 50, 477-482.
DOI: 10.1002/nadc.20020500417
21. Oligosaccharidsynthese für jedermann?
V. Wittmann, Nachr. Chem. 2002, 50, 156-160.
DOI: 10.1002/nadc.20020500212
20. Copper(II)-mediated Activation of Sugar Oxazolines: Mild and Efficient Synthesis of b-Glycosides of N-Acetylglucosamine
V. Wittmann, D. Lennartz, Eur. J. Org. Chem. 2002, 1363-1367.
DOI: 10.1002/1099-0690(200204)2002:8<1363::AID-EJOC1363>3.0.CO;2-#
19. Spatial Screening of Lectin Ligands. Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates
V. Wittmann, S. Seeberger, in Peptides: The Wave of the Future (Proc. 2nd International/17th American Peptide Symposium) (Eds.: M. Lebl, R. A. Houghten), American Peptide Society, San Diego, 2001, pp. 174-176.
18. Combinatorial Solid-Phase Synthesis of Multivalent Cyclic Neoglycopeptides
V. Wittmann, S. Seeberger, Angew. Chem. 2000, 112, 4508-4512; Angew. Chem. Int. Ed. 2000, 39, 4348-4352.
DOI: 10.1002/1521-3757(20001201)112:23<4508::AID-ANGE4508>3.0.CO;2-8 (German) DOI: 10.1002/1521-3773(20001201)39:23<4348::AID-ANIE4348>3.0.CO;2-X (English) Supporting Information - PDF (Size: 9k)
17. Synthesis of Oligosaccharides on Solid Support Using Thioglycosides and Pentenyl Glycosides
V. Wittmann, in Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries (Ed.: P. H. Seeberger), John Wiley & Sons, New York, 2001, pp. 99-116.
DOI: 10.1002/0471220442.ch5
16. Glycoproteins: Properties
V. Wittmann, in Glycoscience: Chemistry and Chemical Biology, Vol. III (Eds.: B. Fraser-Reid, K. Tatsuta, J. Thiem), Springer-Verlag, Heidelberg, 2001, pp. 2289-2303.
15. Glycoproteins: Occurrence and Significance
V. Wittmann, in Glycoscience: Chemistry and Chemical Biology, Vol. III (Eds.: B. Fraser-Reid, K. Tatsuta, J. Thiem), Springer-Verlag, Heidelberg, 2001, pp. 2253-2287.
14. Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates: A Combinatorial Approach
S. Seeberger, V. Wittmann, in Innovation & Perspectives in Solid Phase Synthesis & Combinatorial Libraries 2000 (Ed.: R. Epton), Mayflower Worldwide, Kingswinford, 2001, pp. 355-358.
13. Chemoenzymatic Synthesis and Fluorescent Visualization of Cell-Surface Selectin-Bound Sialyl Lewis X Derivatives
V. Wittmann, A. K. Datta, K. M. Koeller, C.-H. Wong, Chem. Eur. J. 2000, 6, 162-171.
DOI: 10.1002/(SICI)1521-3765(20000103)6:1<162::AID-CHEM162>3.0.CO;2-9
12. Über Strukturen und Überstrukturen
T. Lindel, N. Sewald, V. Wittmann, Nachr. Chem. Tech. Lab. 1999, 47, 16-20.
DOI: 10.1002/nadc.19990470108
11. Ligand Recognition by E- and P-Selectin: Chemoenzymatic Synthesis and Inhibitory Activity of Bivalent Sialyl Lewis x Derivatives and Sialyl Lewis x Carboxylic Acids
V. Wittmann, S. Takayama, K. W. Gong, G. Weitz-Schmidt, C.-H. Wong, J. Org. Chem. 1998, 63, 5137-5143.
DOI: 10.1021/jo980350s Supporting Information - PDF (Size: 233k)
10. Modified Hammerhead Ribozymes as Potential Therapeutics
J. W. Engels, M. Scherr, A. Ganser, M. Grez, V. Wittmann, Nucleosides Nucleotides 1998, 17, 1685-1696.
DOI: 10.1080/07328319808004702
9. Structural Comparison of Oligoribonucleotides and Their 2'-Deoxy-2'-fluoro Analogs by Heteronuclear NMR Spectroscopy
B. Reif, V. Wittmann, H. Schwalbe, C. Griesinger, K. Wörner, K. Jahn-Hofmann, J. W. Engels, W. Bermel, Helv. Chim. Acta 1997, 80, 1952-1971.
DOI: 10.1002/hlca.19970800614
8. 1H-Tetrazole as Catalyst in Phosphoromorpholidate Coupling Reactions: Efficient Synthesis of GDP-Fucose, GDP-Mannose, and UDP-Galactose
V. Wittmann, C.-H. Wong, J. Org. Chem. 1997, 62, 2144-2147.
DOI: 10.1021/jo9620066
7. Mechanism of a-1,3-Fucosyltransferase V: Glycosidic Cleavage Occurs Prior to Nucleophilic Attack
B. W. Murray, V.Wittmann, M. D. Burkart, S.-C. Hung, C.-H. Wong, Biochemistry 1997, 36, 823-831.
DOI: 10.1021/bi962284z
6. S- and C-Glycopeptide Derivatives of an LH-RH Agonist
K. Michael, V. Wittmann, W. König, J. Sandow, H. Kessler, Int. J. Peptide Protein Res. 1996, 48, 59-70.
DOI: 10.1111/j.1399-3011.1996.tb01107.x
5. New Peptidomimetics and Conformational Consequences
H. Kessler, E. Graf von Roedern, E. Lohof, R. Haubner, A. Geyer, V. Wittmann, in Proceedings of the 5th Akabori Conference, German-Japanese Symposium on Peptide Chemistry, May 8-12, 1994, Dresden, FRG (Ed.: E. Wünsch), Max-Planck-Gesellschaft, 1994, pp. 110-115.
4. Preparation and Transmetallation of a Triphenylstannyl ß-D-Glucopyranoside: A Highly Stereo-selective Route to ß-D-C-Glycosides via Glycosyl Dianions
O. Frey, M. Hoffmann, V. Wittmann, H. Kessler, P. Uhlmann, A. Vasella, Helv. Chim. Acta 1994, 77, 2060-2069.
DOI: 10.1002/hlca.19940770730
3. Synthesis of C-Glycosyl Amino Acids and their Use in Solid Phase Peptide Synthesis
V. Wittmann, H. Kessler, in Peptides 1992 (Proc. 22nd European Peptide Symposium) (Eds.: C. H. Schneider, A. N. Eberle), ESCOM Science Publishers, Leiden, 1993, pp. 369-370.
2. Stereoselective Synthesis of C-Glycosides with a Glycosyl Dianion
V. Wittmann, H. Kessler, Angew. Chem. 1993, 105, 1138-1140; Angew. Chem. Int. Ed. Engl.1993, 32, 1091-1093.
DOI: 10.1002/ange.19931050743 (German) DOI: 10.1002/anie.199310911 (English)
1. Synthesis of C-Glycopeptides via Free Radical Addition of Glycosyl Bromides to Dehydroalanine Derivatives
H. Kessler, V. Wittmann, M. Köck, M. Kottenhahn, Angew. Chem. 1992, 104, 874-877; Angew. Chem. Int. Ed. Engl. 1992, 31, 902-904.
DOI: 10.1002/ange.19921040716 (German) DOI: 10.1002/anie.199209021 (English)
+ These authors contributed equally.
Last update: October 5, 2023