Our group is dedicated to the total synthesis of natural products with a unique and complex molecular architecture. In our synthetic planning, Nature serves as a constant source of inspiration, owing to the elegance by which it assembles the most intricate and functional structures. To us, elegance in synthetic terms is best reflected by a domino reaction sequence. Starting from a rather simple molecular intermediate, an avalanche of bond-forming events is triggered. It results in the construction of a highly complex molecular architecture –
ideally the natural product itself.