Better quality control in radiotherapy

From basic research to clinical application: Research team of physical chemist Malte Drescher at the University of Konstanz receives Proof of Concept Grant from the European Research Council for the development of a novel liquid dosimeter.

High-tech microscope for protein structures

Research network at the University of Konstanz is working on advancing and adapting spin-based quantum light microscopy for the structural elucidation of proteins in living cells – 1.3 million euros in funding for the acquisition of the high-tech microscope.


α‑synuclein – the Parkinson’s protein and its membrane interactions

Membrane-binding proteins play key roles in many intracellular processes. A prominent example is α‑synuclein, which is highly abundant in neuronal cells and the main protein component of Lewy bodies, a hallmark of Parkinson´s disease. Lacking a defined three-dimensional structure in solution, it can adopt an α-helical structure when bound to lipid membranes in vitro

Aktuelle Meldung: "On the track of protein-lipid interactions in the cell"


Alzheimer’s and an unusual molecular chaperone

Research team from the University of Konstanz and Utrecht University elucidates the aggregation mechanism of the Alzheimer protein tau

Aktuelle Meldung: Alzheimer’s and an unusual molecular chaperone


University of Konstanz Award for Teaching Excellence (LUKS) 2019 for Professor Malte Drescher (Video in German)

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New protein spin labelling technique

University of Konstanz researchers develop a new site-directed spin labelling approach based on genetically encoded noncanonical amino acids amenable to Diels-Alder chemistry as well as a new spin label, PaNDA.

Aktuelle Meldungen - New protein spin labelling technique


New technique for in-cell distance determination

Researchers from the University of Konstanz, Bielefeld University and ETH Zürich demonstrate for the first time that the pulsed EPR technique RIDME (relaxation-induced dipolar modulation enhancement) can be used for in-cell distance determination in biomacromolecules. Applied within the cell, RIDME improved significantly on conventional double electron-electron resonance (DEER) measurements.

Aktuelle Meldungen - New technique for in-cell distance determination


Official support for "Fridays for Future" movement

In his speech during the closing rally of the demonstration on 15 March 2019, Professor Malte Drescher, a signatory of the "Scientists for Future" initiative and vice rector at the University of Konstanz, pledged the university's support for the protesting school students in Konstanz.

Link to Facebook event

Andreas Scherer on the board of GDCh Division of Magnetic Resonance (FGMR)

On 21 January 2019, Andreas Scherer (Drescher group) was unanimously elected as student representative to the board of the Magnetic Resonance Division of the German Chemical Society GDCh. Congratulations!

Website of the GDCh Division Magnetic Resonance (FGMR)


Election of vice rectors at the University of Konstanz

On 24 October 2018, the Senate of the University of Konstanz elected two vice rectors who will help shape the development of the University over the next three years.  Professor Malte Drescher from the Department of Chemistry will become Vice Rector for Teaching, replacing Professor Matthias Armgardt, who did not stand for re-election.

Current announcements - New vice rectors elected

Dietrich H. Boesken Award 2018 for Anna Bieber as best master's graduate (Video in German)

Anna Bieber (Drescher Group) receives the Dietrich H. Boesken Award 2018 to honour her outstanding achievements as best master's graduate of the year. Established in 2008, the annual award comes with a prize money of 5,000 euros for the best master's graduate at the University of Konstanz. Congratulations!

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Bunsen Master's Award 2018 for Sonja Tischlik

Sonja Tischlik (Drescher Group) receives the Bunsen Master's Award 2018 for her outstanding master's thesis on the topic "Investigating mechanisms of multivalency: Tailored pulses for electron paramagnetic resonance spectroscopy" Congratulations!


Interview of "Labor Praxis" with Malte Drescher

Researchers in Konstanz use molecular spectroscopy to investigate macromolecules directly in their natural environment, the cell. They are particularly interested in so-called intrinsically disordered proteins, which play a key role in Parkinson's and other neurodegenerative diseases.

You can read the full interview online (in German): "Labor Praxis" with Professor Malte Drescher

On the trail of Parkinson’s disease

The molecular causes of diseases such as Parkinson’s need to be understood as a first step towards combating them. University of Konstanz chemists working alongside Professor Malte Drescher recently succeeded in analysing what happens when selective mutations of the alpha-synuclein protein occur – a protein that is closely linked to Parkinson's disease. In a complex series of experiments they examined what the effects were of changing a single amino acid in the protein. The physicochemists were able to prove how this tiny change disturbs the binding of alpha-synuclein to membranes. “We hope that the finding of this selectively defective membrane binding will help us to understand how Parkinson's develops on a molecular level. Ultimately, this will facilitate the devising of therapeutic strategies,” outlines Julia Cattani, a doctoral student, who played a major role in the success of the research. The research results were revealed in the prestigious specialist Journal of the American Chemical Society publication in its 16 March 2017 online edition; a print version is to follow.


 

 

Zukunftskolleg - Alumni Career Paths

Malte Drescher is a Heisenberg Professor at the Department of Chemistry, University of Konstanz. He talked to us about how he got there, his time at the Zukunftskolleg and things he would have done differently. He also shares some valuable advice for young and motivated researchers. Bonus: After reading the text, you will know what "spin markers" are.  


University profile - University of Konstanz in ZEIT Campus

Esther Anandi Kugele, master's programme Life Science:
"I particularly like the family-like atmosphere at the University of Konstanz. I feel cared for here. As a master's student, I am able to participate in important research projects, including currently in my final thesis. Especially as a science student, you are usually in the lab from morning until late afternoon. Being able to go out and relax every so often is thus all the more important. The lake and the university orchestra are perfect for that."